Scientist, Cell Culture Platform Development

SUMMARY:

Cell Culture Development within the Mammalian Platform organization is responsible for the development of cell line and cell culture technologies and processes that support all phases of CMC from pre-candidate selection through BLA.

The Cell Culture Platform Department is a global business unit responsible for the development of cell culture platforms including media and bioprocess technologies for both fed-batch and perfusion from early and late-stage biologics projects, delivering all early phase projects, feasibility evaluation of applying Sanofi cell culture platform for all external project conversion, metabolic profiling, and cell culture pathway analysis for medium and bioprocess development.

We are seeking a highly motivated Scientist to join the Cell Culture Platform team where you will develop and optimize fed-batch and perfusion based upstream cell culture and bioreactor processes. Working closely with other upstream scientists and associates, this lab-based role has an opportunity to deliver technical solutions for the next generation cell culture processes to meet industry demands.

Main Duties & Responsibilities:

• Design, plan, and execute experiments in shake flasks, high throughput bioreactor systems (ambr15/ ambr250) and bench scale bioreactors to optimize upstream cell culture process performance for manufacturing monoclonal antibodies and novel biopharmaceuticals

• Screen and evaluate manufacturing cell lines to support process development for early phase toxicological studies and first in human cGMP manufacturing

• Generate bioreactor material to support the progression of pipeline assets

• Develop and improve platform cell culture media and nutrient feeds to help contribute to evolution of Sanofi's cell culture manufacturing platforms

• Independently conduct experiments, make detailed observations, analyse, and interpret experimental results while exercising appropriate technical discretion

• Prepare technical reports, experimental protocols, and technical summaries for presentation as well as participate in the technology transfer of processes into large scale manufacturing facilities

• Author and contribute to operational documents, templates, and reports within the Cell Culture Platform team

• Perform literature search and cell culture data analysis efficiently, present novel cell culture findings in external conferences, and write peer reviewed publications

• Some weekend working may be required for this role

Basic Qualifications:

• PhD in Chemical/Biochemical Engineering, Biotechnology, Microbiology, Biochemistry, Cell Biology, or a related discipline with 0-2 years of industrial experience or MS with minimum 4 years or BS with minimum 6 years of relevant industrial experience.

• For Ph.D. entry level candidates and/or those without industrial experience, sufficient training on cell culture lab operation will be provided

• Solid understanding of mammalian cell culture and aseptic techniques

• Highly organised, able to prioritise work, work well under pressure and meet deadlines

• High attention to detail, ability to multitask & good communication skills.

Preferred Experience:

• Hands-on experience of bioreactor control systems and operations for mammalian cell culture process development

• Experience with scale-down bioreactor systems such as ambr15 and ambr250

• Knowledge of biochemistry and/or biochemical pathways

• Experience in bioreactor harvest and primary recovery techniques, ideally with mammalian cell culture

• Knowledge of bioreactor process scale-up and technology transfer

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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