21-POS00047159 - Research Associate II, CAR T-Cells
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Xyphos Biosciences , an affiliate of Astellas Pharma Inc. is developing a novel adoptive cell therapy technology platform and building a pipeline of innovative products.
We are a rapidly growing team of research and scientific professionals, passionate about turning science and innovation into medical solutions through our cell therapy technology platform. Through our diversity, scientific knowledge, professional rigor and focus on innovation, we are merging our technology with the Astellas drug development expertise to unlock cures to many therapies. Join our team of committed, enthusiastic professionals devoted to making the most effective, life-saving cell therapy products in the world.
Astellas is announcing a Research Associate II, CAR T-Cells opportunity at their Xyphos site in South San Francisco, CA.
The primary purpose of the Research Associate II is to support discovery efforts for novel chimeric antigen receptor adoptive cell therapies for treatment of cancer. This position will work primarily in a laboratory setting with Scientist and R&D teams.
Essential Job Responsibilities:
Performs immuno-oncology assays (e.g. cytotoxicity, cytokine production) for functional characterization of CAR T and CAR NK cells
Characterizes antibodies by flow cytometry for lead discovery and lead optimization
Adheres to established standard protocols for reliable and consistent data generation
Works independently and with careful attention to detail, records procedure/data/results accurately and in a timely manner, interprets data, draws conclusions, and presents in meetings
Collaborates with other members of the R&D team and with other teams within Astellas
Involved with R&D laboratory operation. Performs other duties or special projects as assigned
BS degree with 3+ years or MS with 0-2 years of laboratory experience in immunology, cancer biology, molecular biology, or similar field
1+ years of relevant hands-on laboratory experience (internship, work, or academic research)
Proficiency at multi-color flow cytometry (4+ channels), including operating flow cytometers, analyzing flow data
Experience in mammalian cell culture, specifically in immune cell functional assays with readouts for at least one: cytotoxicity, activation, proliferation, cytokine secretion
Good math skills and attention to detail in experimentation and record keeping
Eagerness to learn about cutting-edge science in cancer biology, immunology, and CAR-T cells
Willingness to be independent in the lab, excellent work ethic, team-player attitude, crisp communication skills, ability to work weekends as needed
Industry work or internship experience, especially in CAR-T cell or immuno-oncology field
Proficiency in data analysis software (e.g. FlowJo, GraphPad)
Familiarity with one or more of the following techniques: ELISA/ELISPOT/Luminex/CBA/MSD
Familiarity with PBMC isolation from blood products, cell separation techniques
Medical, Dental and Vision Insurance
Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
401(k) match and annual company contribution
Company paid life insurance
Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
Long Term Incentive Plan for eligible positions
Referral bonus program
Category Research and Development
Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans